SIG on Drug Design and Discovery

Chair: Prof. Takuya Kumamoto (Japan)

Vice-Chairs: Prof. Ulrike Holzgrabe (Germany) and Prof. Christopher McCurdy (USA)

The SIG Drug Design and Discovery has succeeded from former SIG Medicinal Chemistry last year.  SIG Drug Design and Discovery aims to develop pharmaceutical sciences related to medicinal chemistry and to bridge pharmacists and pharmaceutical scientists on the viewpoint of drug design and discovery with the following scopes:


(1)   To provide discussion of pharmaceutical science related to medicinal chemistry.

Starting point for the development of new drug is research works in medicinal chemistry.  On working in the area of medicinal chemistry, broad knowledge is necessary on organic chemistry in addition to biochemistry, molecular and structure biology, pharmacology, genetics, toxicology, computer technology, and related disciplines.  In this SIG, participation of pharmaceutical scientists in wide-spread research area is welcome to discuss on drug design and discovery.

Former SIG (SIG Medicinal Chemistry) provided the meeting at FIP Conference on “New Strategies in Modern Medicinal Chemistry” (Istanbul) and “The Need for New Antibiotics Combating Resistant Bacteria” (Lisbon), both demonstrating the translational bridge between chemistry and life sciences.


(2)   To educate pharmacists in research development of drugs discovery.

Process of the discovery of drugs typically involves understanding the character of target organs (enzyme, cell, tissues, etc) related to the disease, setting-up the concept of drug design, providing lead compounds (from traditional medicines, natural products, biological macromolecules, compound library, computational chemistry, etc.), drug design and lead optimization by means of the analysis of structure-activity-relationship.  Deep understanding of this process as well as the mode of action at a molecular level will help pharmacists to choose proper dosage and administration of drugs.


(3)   To provide information and new findings towards drug discovery dependent on the different background.

Drugs play important roles not only as effective substances for the prevention, diagnosis, and treatment of human disease but also those to promote “quality of life” to live a social life getting along with disease, which are dependent on the social, cultural, regional, and generation background.  SIG Drug Design and Discovery will indicate up-to-date information and new findings concerning the development of drug discovery dependent on the different background.

For more information on this SIG, please contact Prof. Kumamoto at