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In vitro and in silico analysis of uptake of sialyl LewisX mimic-decorated liposomes in inflamed endothelial cells
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-B-015-Tuesday
- By: HASHIDA, Mitsuru (Kyoto University, Graduate School of Pharmaceutical Sciences, Kyoto, Japan)
- Co-author(s): Mitsuru Hashida: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
Chanikarn Chantarasrivong: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
Akiharu Ueki: Department of Applied BioorganicChemistry, Gifu University, Gifu, Japan
Shinya Nakamura: Faculty of Pharmacy, Kindai University, Osaka, Japan
Isao Nakanishi: Faculty of Pharmacy, Kindai University, Osaka, Japan
Yuriko Higuchi: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
Hiromune Ando: Department of Applied BioorganicChemistry, Gifu University, Gifu, Japan
Fumiyoshi Yamashita: Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
Makoto Kiso: Department of Applied BioorganicChemistry, Gifu University, Gifu, Japan - Abstract:
Backgrounds
Sialyl LewisX (sLeX) is a natural ligand of E-selectin overexpressed in inflamed endothelium. sLeX is a potential targeting ligand for E-selectin-mediated drug delivery, but the synthesis of sLeX is complicated.
Aims
The aims of this study are (1) to develop liposomes bearing structurally simplified novel sLeX analogs, (2) to characterize
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Last update 28 September 2023