Menu
  • Join
  • Login
  • Contact
 

Search abstracts / presentations


Optimization of drug delivery to tissues and avoiding drug induced phospholipidosis

  • In: Short Communications A2 on Monday, 22 May 2017, 13:30-15:00
  • At: Stockholm (Sweden) (2017)
  • Type: Presentation
  • By: LORYAN, Irena (Uppsala University, Pharmaceutical Biosciences, Uppsla, Sweden)
  • Co-author(s): Irena Loryan: Pharmaceutical Biosciences, Uppsala University, Uppsla, Sweden
    Edmund Hoppe: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Klaus Hansen: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Achim Kless: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Klaus Linz: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Virginia Marossek: Bayer Pharma, Wuppertal, Germany
    Bert Nolte: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Paul Ratcliffe: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Derek Saunders: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Rolf Terlinden: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Anita Wegert: Mercachem, Nijmegen, Netherlands
    Andre Welbers: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Olaf Will: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
    Margareta Hammarlund-Udenaes: Pharmaceutical Biosciences, Uppsala University, Uppsla, Sweden
  • Abstract:

    Backgrounds

    Understanding of the pharmacokinetic basis of drug-induced phospholipidosis (PLD) is limited.

    Aims

    We present a systematic approach to optimize drug delivery to tissues and to provide insight into tissue-specific PLD by evaluation of unbound intracellular and intralysosomal concentrations.

    Methods

    Intra-tissue distribution of the two

    ..

  • The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress. Please login
Last update 28 September 2023

FIP Congresses