3D QSAR-guided identification of oxazole and triazole derivatives as novel, potent and selective S1P1 agonists

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-049-Monday
• By: WANG, Xiaojian (Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Medicinal Chemistry, Beijing, China)
• Co-author(s): Xiaojian Wang: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Dali Yin: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Qiong Xiao: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Meiyang Xi: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Hui Wen: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Xiang Zhang: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  Huaqing Cui: Medicinal Chemistry, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  
• Abstract:

  Backgrounds

  Recently, the Sphingosine 1-phosphate receptor (S1P-R) signaling system has proven to be of biological and medical importance in immune regulation, including blood vessel constriction, heart rate modulation, angiogenesis, etc.

  Aims

  To design novel, potent and selective S1P₁ agonists with improved pharmacokinetic profiles based on the
  ..

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