High brain uptake of GABAA antagonist oroxylin A leads to lack of anxiolytic effect of Radix Scutellariae

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-022-Tuesday
• By: ZUO, Joan (The Chinese University of Hong Kong, School of Pharmacy, Shatin, Hong Kong SAR China)
• Co-author(s): Sophia Fong: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
  Chenrui LI: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
  Yiu Cheong Ho: Division of Life Science and Applied Genomic Center, The Hong Kong University of Science and Technology, Hong Kong
  Rui Li: Division of Life Science and Applied Genomic Center, The Hong Kong University of Science and Technology, Hong Kong
  Qian Wang: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
  Eric Wong: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
  Hong Xue: Division of Life Science and Applied Genomic Center, The Hong Kong University of Science and Technology, Hong Kong
  Joan Zuo: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
  
• Abstract:

  Backgrounds

  Although flavones from Radix Scutellariae (RS) were reported to have CNS activities with baicalein (B), wogonin (W) and baicalin (BG) identified to be positive modulators of the benzodiazepine binding site of GABA_A receptors and oroxylin A (OA) to be a GABA_A antagonist, their brain uptake has never been fully investigated. 

  Aims

  The
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