Effects of CES1 genetic variants on its gene expression, and clopidogrel pharmacokinetics and pharmacodynamics

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-050-Tuesday
• By: NEUVONEN, Mikko (University of Helsinki, Clinical Pharmacology, Helsinki, Finland)
• Co-author(s): Mikko Neuvonen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  Katriina Tarkiainen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  Aleksi Tornio: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  Päivi Hirvensalo: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  Tuija Tapaninen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  Maria Paile-Hyvärinen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  Matti Itkonen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  Mikko Holmberg: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  Vesa Kärjä: Department of Pathology, Kuopio University Hospital, Kuopio, Finland
  Ville Männistö: Department of Medicine, University of Eastern Finland, Kuopio, Finland
  Pertti Neuvonen: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  Jussi Pihlajamäki: Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland;Clinical Nutrition and Obesity Center, Kuopio University Hospital, Kuopio, Finland
  Janne Backman: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  Mikko Niemi: Department of Clinical Pharmacology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  
• Abstract:

  Backgrounds

  Although carboxylesterase 1 (CES1) has a recognized role in drug metabolism and its activity shows marked interindividual variability, few studies have investigated the effects of genetic variants on CES1 expression in humans.

  Aims

  Our aim was to investigate effects of genetic variants on CES1 gene expression, and clopidogrel

  ..

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