Direct Nose to Brain Delivery of CNS Drugs: Effect of Glymphatic System on Brain Pharmacokinetics and Distribution after Intranasal Application

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-088-Tuesday
• By: INOUE, Daisuke (Shujitsu University, School of Pharmacy, Okayama, Japan)
• Co-author(s): Daisuke Inoue: School of Pharmacy, Shujitsu University, Okayama, Japan
  Akiko Tanaka: Kyoto Pharmaceutical University, Kyoto, Japan
  Kosuke Kusamori: Kyoto Pharmaceutical University, Kyoto, Japan
  Hidemasa Katsumi: Kyoto Pharmaceutical University, Kyoto, Japan
  Akira Yamamoto: Kyoto Pharmaceutical University, Kyoto, Japan
  Toshiyasu Sakane: Kobe Pharmaceutical University, Kobe, Japan
  Tomoyuki Furubayashi: School of Pharmacy, Shujitsu University, Okayama, Japan
  
• Abstract:

  Backgrounds

  "EN-US">Nasal cavity is connected anatomically with the brain and the drug applied nasally can gain easy access to the brain.

  Aims

  "EN-US">The purpose of the study is to assess the pharmacokinetics of drugs applied nasally to rats, and to investigate the effect of the fluid circulation system in the brain, called glymphatic system, on
  ..

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