Determining the solubility of olanzapine in poly(lactic-co-glycolic acid) (PLGA) using differential scanning calorimetry (DSC) and hot stage microscopy (HSM)

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-C-005-Tuesday
• By: ASKIN, Sean (University College London, School of Pharmacy, London, United Kingdom)
• Co-author(s): Sean Askin: UCL School of Pharmacy, University College London, London, United Kingdom
  Min Zhao: School of Pharmacy, Queen's University Belfast, Belfast, United Kingdom
  Andrea Domingues-Goncalves: DPDD Drug Delivery, GlaxoSmithKline R&D, Stevenage, United Kingdom
  Simon Gaisford: UCL School of Pharmacy, University College London, London, United Kingdom
  Duncan Craig: UCL School of Pharmacy, University College London, London, United Kingdom
  
• Abstract:

  Backgrounds

  Determining the solubility level of a drug in a polymer is important because it defines the maximum drug load in a solid dispersion that is thermodynamically stable and hence will not undergo changes in the physical state over time. Measuring solubility in polymers, however, is difficult due to the high viscosity of these systems...

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