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Optimization of drug delivery to tissues and avoiding drug induced phospholipidosis
- In: Short Communications A2 on Monday, 22 May 2017, 13:30-15:00
- At: Stockholm (Sweden) (2017)
- Type: Presentation
- By: LORYAN, Irena (Uppsala University, Pharmaceutical Biosciences, Uppsla, Sweden)
- Co-author(s): Irena Loryan: Pharmaceutical Biosciences, Uppsala University, Uppsla, Sweden
Edmund Hoppe: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
Klaus Hansen: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
Achim Kless: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
Klaus Linz: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
Virginia Marossek: Bayer Pharma, Wuppertal, Germany
Bert Nolte: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
Paul Ratcliffe: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
Derek Saunders: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
Rolf Terlinden: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
Anita Wegert: Mercachem, Nijmegen, Netherlands
Andre Welbers: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
Olaf Will: Global Preclinical R&D, Grünenthal GmbH, Aachen, Germany
Margareta Hammarlund-Udenaes: Pharmaceutical Biosciences, Uppsala University, Uppsla, Sweden - Abstract:
Backgrounds
Understanding of the pharmacokinetic basis of drug-induced phospholipidosis (PLD) is limited.Aims
We present a systematic approach to optimize drug delivery to tissues and to provide insight into tissue-specific PLD by evaluation of unbound intracellular and intralysosomal concentrations.Methods
Intra-tissue distribution of the two.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023