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A quality-by-design approach for highly systematic optimization of lipid-polymer hybrid nanoparticles toward efficient and safe intracellular delivery of siRNA cargo
- In: Short Communications C2 on Tuesday, 23 May 2017, 11:15-12:30
- At: Stockholm (Sweden) (2017)
- Type: Presentation
- By: THANKI, Kaushik (University of Copenhagen, Department of Pharmacy, Copenhagen, Denmark)
- Co-author(s): Kaushik Thanki: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
Xianghui Zeng: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
Sarah Justesen: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark;Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
Sarah Tejlmann: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
Emily Falkenberg: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
Hanne Mørck Nielsen: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark
Henrik Franzyk: Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark
Camilla Foged: Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark - Abstract:
Backgrounds
RNA interference therapy is highly target-specific and is mediated by small interfering RNA (siRNA).Aims
The aim of the study was to apply a quality-by-design approach for the systematic optimization of siRNA-loaded lipid-polymer hybrid nanoparticles (LPNs) composed of lipid-like materials (lipidoids) and poly(DL-lactide-co-glycolide.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023