Engineering of KR-12 derived from human host defence peptide LL-37 into stable, selective and potent antimicrobial drug lead
- In: Short Communications A1 on Monday, 22 May 2017, 13:30-15:00
- At: Stockholm (Sweden) (2017)
- Type: Presentation
- By: MUHAMMAD, Taj (Uppsala University, Medicinal Chemsitry, Uppsala, Sweden)
- Co-author(s): Taj Muhammad : Medicinal Chemsitry, Uppsala University, Uppsala, Sweden
Sunithi Gunasekera: Medicinal Chemsitry, Uppsala University, Uppsala, Sweden
Adam A. Strömstedt: Medicinal Chemsitry, Uppsala University, Uppsala, Sweden
Ulf Goransson: Medicinal Chemsitry, Uppsala University, Uppsala, Sweden - Abstract:
Backgrounds
The human cathelicidin LL-37 is a multifunctional host defence molecule that mediates various host responses including antimicrobial action, chemotaxis, epithelial cell activation, angiogenesis, epithelial wound repair and activation of chemokine secretion. However, LL-37 encounters the generic problems common to most linear counter.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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