Acute and delayed effects of cisplatin and methotrexate administration on intestinal substance P dynamics in rats
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-035-Tuesday
- By: HIRAFUJI, Masahiko (School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Department of Pharmacological Sciences, Ishikari-Tobetsu, Japan)
- Co-author(s): Saki Shiga: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
Takuji Machida: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
Mikiko Yutani: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
Maiko Machida: Division of Pharmacotherapy, Hokkaido Pharmaceutical University School of Pharmacy, Sapporo, Hokkaido, Japan
Kenji Iizuka: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan
Masahiko Hirafuji: Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido, Japan - Abstract:
Backgrounds
Intestinal substance P is considered to involve in the mechanism of cancer chemotherapy-induced nausea and vomiting.Aims
The aim of this study was to compare the intestinal substance P metabolism after a single administration to rats of cisplatin or methotrexate, which have different emetogenicity in humans.Methods
Rats were i.p. injected .. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023