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Influence of hpmc on dissolution and supersaturation characteristics

  • In: Posters I - Regulatory Sciences
  • At: PSWC, Melbourne (Australia) (2014)
  • Type: Poster
  • Poster code: PI-007
  • By: RUFF, Aaron (Goethe University, Institute for Pharmaceutical Technology, Frankfurt am main, Germany)
  • Co-author(s): Kesisoglou, Filippos (Merck & Co., Inc., Whitehouse station, United States of America)
    Wang, Michael (Merck & Co., Inc., Whitehouse station, United States of America)
    Xu, Wei (Merck & Co., Inc., Whitehouse station, United States of America)
    Dressman, Jennifer (Goethe University, Frankfurt am main, Germany)
  • Abstract:

    Background
    Most new drugs in development exhibit solubility limited bioavailability. One way to bypass this limitation is to promote and extend the duration of supersaturation in the small intestine. As an excipient, HPMC is known to increase the solubility and dissolution behavior of poorly soluble drugs and to have a direct influence of the..

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Last update 28 September 2023

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