Thiopurine s-methyltransferase (tpmt) phenotypes in the nigerian population

• In: Posters J - Translational Research and Individualized Medicines
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PJ-001
• By: BOLAJI, Oluseye (Obafemi Awolowo University, Department of Pharmaceutical Chemistry, Ile-ife, Nigeria)
• Co-author(s): Adehin, Ayo (Obafemi Awolowo University, Ile-ife, Nigeria)
  
• Abstract:

  Background: Thiopurine S-methyltransferase (TPMT), a polymorphic enzyme, catalyses the methylation of thiopurine drugs. Mild to severe myelosuppression, at times lethal, are characteristic of certain phenotypes.
  Aim:This study investigated TPMT phenotypes in a Nigerian population in order to derive reference values for the enzyme's activity in the ..

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