Menu
  • Join
  • Login
  • Contact
 

Search abstracts / presentations


Accounting for ethnic and sex differences in qtc prolongation using heart drug concentrations with physiologically based pharmacokinetic/pharmacodynamic (pbpk/pd) models

  • In: Posters: Pharmacokinetics/Pharmacodynamics & Systems Pharmacology
  • At: Bangkok (Thailand) (2014)
  • Type: Poster
  • Poster code: POS-PAA002
  • By: CHETTY, Manoranjenni (Simcyp Ltd (A Certara company), Sheffield, United Kingdom)
  • Co-author(s): Polak, Sebastian (Simcyp Ltd (A Certara company), Sheffield, United Kingdom)
    Jamei, Masoud (Simcyp Ltd (A Certara company), Sheffield, United Kingdom)
    Rostami, Amin (Simcyp Ltd (A Certara company), Sheffield, United Kingdom)
  • Abstract:

    I. Background: Ethnic and sex differences in QTc prolongation are poorly understood.
    II. Aims: To develop a PBPK/PD model linking unbound quinidine concentrations in the heart to QT prolongation for comparison of quinidine effects in Caucasians and Asians of both sexes.
    III. Methods: The Simcyp Population Based Simulator was used to simulate the..

  • The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress. Please login
Last update 28 September 2023

FIP Congresses