DELINEATING INTER-INDIVIDUAL VARIABILITY IN SYSTEMIC EXPOSURE OF ORAL GABAPENTIN

• In: B2 - Reducing inter-individual variability: the power of a practitioner/scientist team approach on Thursday, 1 October 2015, 14:30-17:30
• At: Düsseldorf (Germany) (2015)
• Type: Presentation
• By: PAULETTI, Giovanni (University of Cincinnati, Winkle College of Pharmacy, Cincinnati, United States)
• Co-author(s): Giovanni Pauletti
  
• Abstract:

  Clinical trials demonstrated that oral gabapentin is effective in managing pain symptoms associated with postherpetic neuralgia. Unfortunately, the pharmacodynamic response is inconsistent, with less than half of the patients experiencing > 50% improvement in pain scores when compared to baseline. To explore underlying mechanisms of this

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