Improved cost-effective HPLC method for the separation of dropropizine enantiomers using cellulose based chiral stationary phase

• In: SIG Pharmaceutical Biotechnology - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: PB-P-001
• By: VALLIAPPAN, Kannappan (Annamalai University, Dept. of Pharmacy, Annamalainagar 608 002, India)
• Co-author(s): K, Chandrasekaran (Spinco Laboratory Pvt Ltd., Applications, INSTRUMENTATION CENTRE, GUINDY, CHENNAI, India)
  R, Manavalan (Annamalai University, Dept. of Pharmacy, ANNAMALAINAGAR 608 002, India)
  M, Subbarayan (Spinco Laboratory Pvt Ltd., Applications, INSTRUMENTATION CENTRE, GUINDY, CHENNAI, India)
  
• Abstract:

  Dropropizine in its levo-form is an established antitussive agent. The same has a monograph in British Pharmacopoeia 2004, BP 2004, (Ph Eur monograph 1535). Dextrodropropizine is a known impurity in levodropropizine and requires enantiomeric purity test. An enantiospecific HPLC method for separation of dropropizine enantiomers in pharmaceutical

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