Benzoylurea derivatives as a novel class of cancericidal tubulin ligands: synthesis, activities and structure-activity relationships

• In: SIG Individualised Medicine - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: IM-P-006
• By: SONG, Danqing (Institute of Medicinal Biotechnology, Beijing, China)
• Co-author(s): Yang, Peng (Institute of Medicinal Biotechnology, BEIJING, China)
  Wang, Yan (Institute of Medicinal Biotechnology, BEIJING, China)
  Wang, Yonghong (Institute of Medicinal Biotechnology, BEIJING, China)
  Wu, lianzong (Institute of Medicinal Biotechnology, BEIJING, China)
  Wang, yueming (Institute of Medicinal Biotechnology, BEIJING, China)
  Li, yinghong (Institute of Medicinal Biotechnology, BEIJING, China)
  Jiang, jiandong (Institute of Medicinal Biotechnology, BEIJING, China)
  
• Abstract:

  As a part of our continuing search for potential anticancer drug candidates and discussion for SAR in 3-haloacylamino benzoylurea (HBU) series, we designed and synthesized 46 new derivatives based on the lead compounds 3-IAABU, 3-BAABU and JIMB01. Systematic SAR studies indicated that: (i) the active site of the β-tubulin is not..

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