Could toxicities due to cisplatin be ameliorated with the use of N-acetylcysteine? A randomized double-blind placebo-controlled trial

• In: Poster presentation
• At: Buenos Aires (Argentina) (2016)
• Type: Poster
• Poster code: POS-HPS-080
• By: VISACRI, Marília (School of Medical Sciences (FCM), University of Campinas, Campinas, Brazil)
• Co-author(s): Marília Berlofa Visacri:,School of Medical Sciences (FCM), University of Campinas,Campinas,Brazil|Júlia Quintanilha:,School of Medical Sciences (FCM), University of Campinas,Campinas,Brazil|Vanessa Sousa:,Faculty of Pharmaceutical Sciences (FCF), University of Campinas,Campinas,Brazil|Gabriela De Vito:,Faculty of Pharmaceutical Sciences (FCF), University of Campinas,Campinas,Brazil|Rosiane Ambrósio:,School of Medical Sciences (FCM), University of Campinas,Campinas,Brazil|Luciane Calonga:,Clinical Hospital, University of Campinas,Campinas,Brazil|Silvia Curi:,Clinical Hospital, University of Campinas,Campinas,Brazil|Carlos Chone:,Clinical Hospital, University of Campinas,Campinas,Brazil|Carmen Lima:,School of Medical Sciences (FCM), University of Campinas,Campinas,Brazil|Patricia Moriel:,Faculty of Pharmaceutical Sciences (FCF), University of Campinas,Campinas,Brazil
  
• Abstract:

  Cisplatin chemotherapy induces oxidative stress and therefore has consequent toxicities. The protective antioxidant role of N-acetylcysteine (NAC) on toxicity due to cisplatin has been reported in experimental models; however, its efficacy in patients has not been elucidated. 

  A pilot study was conducted with 12 patients undergoing treatment with

  ..

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