Cyclosporine main metabolite m17 as an adequate index in pharmacokinetic variation and dose adjustment in kidney transplantation

• In: SIG Bioavailability/Bioequivalence - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: BB-P-041
• By: TAJERZADEH, Hosnieh (Faculty of pharmacy, tehran university, Tehran, Iran)
• Abstract:

  Cyclosporine A (CyA), is the most effective immunosuppressive drug, completely eliminated through hepatic metabolism, mainly by CYP3A4 system. Among more than 25 identified metabolites, M17 is the main metabolite with 10 percent of CyA activity
  
  AIM: The aim of present study is to useM17 as an index to evaluate pharmacokinetic variation and..

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