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Engineering of KR-12 derived from human host defence peptide LL-37 into stable, selective and potent antimicrobial drug lead

  • In: Short Communications A1 on Monday, 22 May 2017, 13:30-15:00
  • At: Stockholm (Sweden) (2017)
  • Type: Presentation
  • By: MUHAMMAD, Taj (Uppsala University, Medicinal Chemsitry, Uppsala, Sweden)
  • Co-author(s): Taj Muhammad : Medicinal Chemsitry, Uppsala University, Uppsala, Sweden
    Sunithi Gunasekera: Medicinal Chemsitry, Uppsala University, Uppsala, Sweden
    Adam A. Strömstedt: Medicinal Chemsitry, Uppsala University, Uppsala, Sweden
    Ulf Goransson: Medicinal Chemsitry, Uppsala University, Uppsala, Sweden
  • Abstract:

    Backgrounds

    The human cathelicidin LL-37 is a multifunctional host defence molecule that mediates various host responses including antimicrobial action, chemotaxis, epithelial cell activation, angiogenesis, epithelial wound repair and activation of chemokine secretion. However, LL-37 encounters the generic problems common to most linear counter..

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Last update 28 September 2023

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