A new ruthenium complex containing xanthoxylin induces cell cycle arrest in the S phase and causes cell death by apoptosis

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-005-Monday
• By: BEZERRA, Daniel (Fundação Oswaldo Cruz, Laboratório de Engenharia Tecidual e Imunofarmacologia, Salvador, Brazil)
• Co-author(s): Nanashara Carvalho: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Salvador, Brazil
  Sara Neves: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Salvador, Brazil
  Regina Oliveira: Department of Chemistry, Federal University of São Carlos, São Carlos, Brazil
  Milena Soares: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Salvador, Brazil
  Rose Carlos: Department of Chemistry, Federal University of São Carlos, São Carlos, Brazil
  Paulo Nogueira: Department of Chemistry, Federal University of Sergipe, São Cristóvão, Brazil
  Daniel Bezerra: Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ), Salvador, Brazil
  
• Abstract:

  Backgrounds

  Ruthenium complexes are of interest as antitumor agents because they have selective anticancer properties and low systemic toxicity. 

  Aims

  The aim of this work was to investigate the underlying mechanisms of the cytotoxicity of cis-[Ru(phen)₂(xant)](PF₆), a new ruthenium complexe containing xanthoxylin (CXR). 

  Methods

  CXR was tested against

  ..

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