Investigation of pulmonary drug permeability and tissue retention by computational analysis of rat ex vivo lung absorption profiles

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-010-Tuesday
• By: ERIKSSON, Johanna (Uppsala University, Department of Pharmacy, Uppsala, Sweden)
• Co-author(s): Johanna Eriksson: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  Erik Sjögren: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  Helena Thörn: Pharmaceutical Development Inhalation, AstraZeneca-Gothenburg, Gothenburg, Sweden
  Katarina Rubin: Respiratory, Inflammation and Autoimmunity, Innovative Medicine and Early Development, AstraZeneca-Gothenburg, Gothenburg, Sweden
  Per Bäckman: Current adress: Mylan Global Respiratory Group, Mylan Pharma UK Ltd, Kent, United Kingdom;Pharmaceutical Development Inhalation, AstraZeneca-Gothenburg, Gothenburg, Sweden
  Hans Lennernäs: Department of Pharmacy, Uppsala University, Uppsala, Sweden
  
• Abstract:

  Backgrounds

  To achieve an optimal drug delivery to the lung by pharmaceutical formulation it is important to have knowledge not only about residence time and drug release, but also of the rate and mechanisms of pulmonary permeability and tissue retention processes.

  Aims

  The aim of this study was to investigate the overall pulmonary absorption of drug
  ..

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