Polymer-functionalized Silica-Lipid Hybrid for Improving the Oral Delivery of Poorly Water-Soluble Weak Base Drugs

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-B-107-Tuesday
• By: RAO, Shasha (University of South Australia, School of Pharmacy and Medical Sciences, Adelaide, Australia)
• Co-author(s): Shasha Rao: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
  Katharina Richter: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
  Tri-Hung Nguyen: Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia
  Ben Boyd: Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia;ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Australia
  Christopher Porter: Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia;ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Australia
  Angel Tan: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
  Clive Prestidge: School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia
  
• Abstract:

  Backgrounds

  Silica lipid hybrid (SLH) microparticles are an efficient solid-state lipid-based carrier for the oral delivery of poorly water-soluble compounds.

  Aims

  This study focuses on combining the advantages of SLH with the benefits of Pluronic (Plu) F127 to control lipid digestion and drug release, hence enhancing the oral absorption.

  Methods

  Cinnar

  ..

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