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Uptake of cocaine, opioids and other organic cations at the blood-brain barrier

  • In: Symposium A2: Systems approaches to modeling the contribution of transporters in drug disposition, response and toxicity on Tuesday, 23 May 2017, 09:40-10:15
  • At: Stockholm (Sweden) (2017)
  • Type: Presentation
  • By: SCHERRMANN, Jean-Michel (University Paris Descartes, INSERM, Pharmacokinetics, PARIS, France)
  • Co-author(s): Jean-Michel Scherrmann: Pharmacokinetics, University Paris Descartes, INSERM 1144, PARIS, France
  • Abstract:

    Brain uptake of most psychoactive molecules is mainly believed to occur by passive diffusion although these molecules are mostly cationic at the physiological pH 7.4.

     

    Recent studies have seriously challenged this well-established assumption following the discovery that an active uptake component may be more important that the single passive

    ..

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Last update 28 September 2023

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