Pharmacological evaluation of antidepressant effect of novel n-substituted benzamides

• In: SIG: Medicinal Chemistry - Posters
• At: Basel (Switzerland) (2008)
• Type: Poster
• Poster code: MC-P-014
• By: CHIRITA, Cornel (University of Medicine and Pharmacy 'Carol Davila' Bucharest, Bucharest, Romania)
• Co-author(s): Negres, Simona (University of Medicine and Pharmacy 'Carol Davila' Bucharest, Romania)
  Marineci, Cristina Daniela (University of Medicine and Pharmacy 'Carol Davila' Bucharest, Romania)
  Arsene, Andreea (University of Medicine and Pharmacy 'Carol Davila' Bucharest, Romania)
  Zbarcea, Cristina (University of Medicine and Pharmacy 'Carol Davila' Bucharest, Romania)
  Nuta, Diana (University of Medicine and Pharmacy 'Carol Davila' Bucharest, Romania)
  Cristea, Aurelia Nicoleta (University of Medicine and Pharmacy 'Carol Davila' Bucharest, Romania)
  
• Abstract:

  The new synthesized N-(2-dialkylaminoethyl)-N-(3-chlorophenyl)-benzamides, conventionally named I 5C, I 14C and II 5C, are structurally related to tiapride, sulpiride or amisulpride, drugs mainly used in the treatment of psychosis and depressive states. This dual activity is based on the dose-dependent antagonist properties towards dopamine..

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