Combined application of pharmacokinetics, pharmacodynamics and pharmacogenetics: an effective approach to optimize antiretroviral therapy in hiv infected patients

• In: SIG: Individualised Medicine - Posters
• At: Basel (Switzerland) (2008)
• Type: Poster
• Poster code: IM-P-005
• By: CABRERA, Salvador (Hospital Universitario de Salamanca, Salamanca, Spain)
• Co-author(s): García, María José (Universidad de Salamanca, Spain)
  Valverde, María Paz (Hospital Universitario de Salamanca, SALAMANCA, Spain)
  Cordero, Miguel (Hospital Universitario de Salamanca, SALAMANCA, Spain)
  Iglesias, Alicia (Hospital Universitario de Salamanca, SALAMANCA, Spain)
  Domínguez-Gil, Alfonso (Hospital Universitario de Salamanca, SALAMANCA, Spain)
  
• Abstract:

  Efavirenz (EFV) is widely used in HIV-infected patients. The present study aimed to evaluate the combined clinical application of pharmacogenetics, pharmacodynamics and therapeutic drug monitoring (TDM) to optimize EFV therapy.
  
  The study was carried out on 32 patients who had been treated with EFV for at least one year. Drug plasma concentrations ..

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