Estimation of the influence of valproate,carbamazepine, phenobarbital and phenytoin on oral clearance of topiramate with nonmem

• In: Hospital Pharmacy - Posters
• At: Istanbul (Turkey) (2009)
• Type: Poster
• Poster code: HPS-P-109
• By: JIANG, Dechun (Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing, China)
• Co-author(s): Zeng, Yan (Department of Pharmacy, Xuanwu Hospital of Capital Medical University, BEIJING, China)
  Yang, Yang (Department of Pharmacy, Xuanwu Hospital of Capital Medical University, BEIJING, China)
  Wang, Yuqin (Department of Pharmacy, Xuanwu Hospital of Capital Medical University, BEIJING, China)
  
• Abstract:

  To estimate the effect of valproate, carbamazepine, phenobarbital, phenytoin on the oral clearance of topiramate. 192 blood samples were taken from 144 epileptic outpatients or inpatients who had taken topiramate for more than 7 days, and the serum concentrations of topiramate were assayed by HPLC-RF method with pre-column derivatization. Because..

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