Active metabolites formed during hepatic first-pass: simulations featuring their contribution to the overall effect in altered liver clearance and drug-drug interactions

• In: Bioavailability/Bioequivalence - Posters
• At: Istanbul (Turkey) (2009)
• Type: Poster
• Poster code: BB-P-007
• By: ABDELAZIZ, Ahmed (German University in Cairo, Cairo, Egypt)
• Co-author(s): Alaraby, Mohammad (German University in Cairo, CAIRO, Egypt)
  Mahran, Laila (German University in Cairo, CAIRO, Egypt)
  Spahn-Langguth, Hilde (University of Graz, GRAZ, Austria)
  
• Abstract:

  Phase-I- and - occasionally - also phase-II metabolites may contribute to the overall effect of a drug. This is not always apparent or revealed, since total concentrations of metabolites may be low in relation to parent drug concentrations. In the case of carvedilol, using a comparison of HPLC and beta 1-specific radioligand-receptor-binding assay ..

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