Activity and genotype of thiopurine s-methyltransferase(tpmt) related to adverse reactions in leukemic child patients under the maintenance therapy with 6-mercaptopurine(6mp)

• In: Hospital Pharmacy Section - Poster session
• At: Cairo (Egypt) (2005)
• Type: Poster
• Poster code: HPS-P-076
• By: IWAMOTO, Kikuo (Shimane University Hospital, Pharmacy, Izumo, Japan)
• Co-author(s): Naora (Shimane University Hospital, IZUMO, Japan)
  Nishimura (Shimane University Hospital, IZUMO, Japan)
  Iwase (Shimane University Hospital, IZUMO, Japan)
  Kanai (Shimane University Hospital, IZUMO, Japan)
  Taketani (Shimane University Hospital, IZUMO, Japan)
  Yamaguchi (Shimane University Hospital, IZUMO, Japan)
  
• Abstract:

  Aim: Activity and genotype of TPMT were studied to explain cause of severe adverse reactions in leukemic child patients under the maintenance therapy with 6MP.
  
  Methods: Three patients(3, 4 and 14 y.o.) with acute ALL participated in this study after the informed consents were obtained, whereas one patient(15 y.o.) with ML participated there..

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