The serotonin 5-ht3 receptor c and e subunits influence the response to antagonists

• In: SUBMITTED ORALS on Monday, 14 April 2014, 14:00-15:30
• At: PSWC, Melbourne (Australia) (2014)
• Type: Presentation
• By: IRVING, Helen (Monash University, Drug Discovery Biology, Parkville, Australia)
• Co-author(s): Yaakob, Nor (Monash University, Parkville, Australia)
  Nguyen, Dan-Thanh (Monash University, Parkville, Australia)
  Exintaris, Betty (Monash University, Parkville, Australia)
  
• Abstract:

  Background: The serotonin (5-hydroxytryptamine) 5-HT3 receptor is a ligand gated ion channel found both peripherally and centrally and 5-HT3 receptor antagonists are used to treat various conditions such as irritable bowel syndrome (IBS), chemotherapy induced nausea and vomiting (CINV) and depression. The 5-HT3 receptor consists of various..

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