Targeted inhibition of atp-bing cassette transporter a1 protein degradation promotes reverse cholesterol transport and reduces atherosclerosis in mice

• In: Posters G - Pharmacokinetics (PK), Pharmacodynamics (PD) and Systems Pharmacology
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PG-048
• By: ZHU, Haibo (Beijing, China)
• Co-author(s): Huang, LinZhang (, Beijing, China)
  Fan, BaoYan (, Beijing, China)
  
• Abstract:

  Objective
  ATP-Bing Cassette Transporter A1 (ABCA1) is a key protein in the rate-limiting step of reverse cholesterol transport, which maintains plasma HDL levels. Transcriptional regulating ABCA1 promotes HDL generation and RCT is well established, however, little is known about the posttranspcriptional inhibition of ABCA1 degradation on..

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