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High brain uptake of GABAA antagonist oroxylin A leads to lack of anxiolytic effect of Radix Scutellariae
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-022-Tuesday
- By: ZUO, Joan (The Chinese University of Hong Kong, School of Pharmacy, Shatin, Hong Kong SAR China)
- Co-author(s): Sophia Fong: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
Chenrui LI: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
Yiu Cheong Ho: Division of Life Science and Applied Genomic Center, The Hong Kong University of Science and Technology, Hong Kong
Rui Li: Division of Life Science and Applied Genomic Center, The Hong Kong University of Science and Technology, Hong Kong
Qian Wang: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
Eric Wong: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong
Hong Xue: Division of Life Science and Applied Genomic Center, The Hong Kong University of Science and Technology, Hong Kong
Joan Zuo: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong - Abstract:
Backgrounds
Although flavones from Radix Scutellariae (RS) were reported to have CNS activities with baicalein (B), wogonin (W) and baicalin (BG) identified to be positive modulators of the benzodiazepine binding site of GABAA receptors and oroxylin A (OA) to be a GABAA antagonist, their brain uptake has never been fully investigated.Aims
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Last update 28 September 2023