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Modulation of P-glycoprotein function and sensitivity to anticancer drug by Azadirachta indica extract in multidrug resistant cell lines
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-081-Monday
- By: KAWAMI, Masashi (Hiroshima University, Graduate school of Biomedical & Health Sciences, Pharmaceutics and Therapeutics, Hiroshima, Japan)
- Co-author(s): Masashi Kawami: Pharmaceutics and Therapeutics, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan
Yukinori Yamada: Pharmaceutics and Therapeutics, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan
Ousanee Issarachot: Center of Excellence in Innovative Drug Delivery and Nanomedicine, Mahidol University, Bangkok, Thailand
Varaporn Junyaprasert: Center of Excellence in Innovative Drug Delivery and Nanomedicine, Mahidol University, Bangkok, Thailand
Ryoko Yumoto: Pharmaceutics and Therapeutics, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan
Mikihisa Takano: Pharmaceutics and Therapeutics, Graduate school of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan - Abstract:
Backgrounds
P-Glycoprotein (P-gp; ABCB1), a member of ATP-binding cassette transporters, is well known to confer multidrug resistance to various cancer cells. At this moment, however, P-gp modulator is not yet available for clinical use, partly due to the toxicity of the modulator. We have been studying P-gp modulating effects of various Thai plant .. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023