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Use of 'Extended Clearance Concept' in new drug discovery and development; application to a drug classification system and to a design of clinical studies
- In: Keynote 4 - Ensuring public healthcare quality through pharmacopeia standards and related programs on Tuesday, 23 May 2017, 14:00-15:00
- At: Stockholm (Sweden) (2017)
- Type: Presentation
- By: SUGIYAMA, Yuichi (RIKEN Innovation center, Sugiyama laboratory, Yokohama, Japan)
- Co-author(s): Yuichi Sugiyama: Sugiyama Laboratory, Riken, Yokohama, Japan
- Abstract:
Even when drugs ultimately undergo metabolism and/or biliary excretion in the liver, their elimination rate is sometimes determined by the hepatic uptake rate mediated by uptake transporters. Elucidation of the rate-determining process is therefore critical for predicting their hepatic clearance, and their systemic and regional exposures. I will
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Last update 28 September 2023