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Enhanced brain targeting by synthesis of a prodrug n-octanoyl lamivudine-5-octanoate and its incorporation in to solid lipid nanoparticles
- In: Industrial Pharmacy - Posters
- At: Basel (Switzerland) (2008)
- Type: Poster
- Poster code: IPS-P-051
- By: DAHIMA, Rashmi (SOPS,RGTU, Bhopal, India)
- Co-author(s): Chandra Bose, Karthikeyan (SOPS,RGTU, BHOPAL, India)
Pachori, Ashish (SOPS,RGTU, BHOPAL, India)
Patil, Pravin (SOPS,RGTU, BHOPAL, India) - Abstract:
To overcome the limited access of the drug Lamivudine to the brain, N-Octanoyl lamivudine-5-
Octanoate was synthesized and incorporated into solid lipid nanoparticles (Noctanoyllamivudine-
5-octanoate-SLN). N-octanoyllamivudine-5-octanoate was synthesized by
dissolving the lamivudine in pyridine then adding the octanoyl chloride with continuous
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Last update 28 September 2023