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Functional characterization of 21 allelic variants of dihydropyrimidinase
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-047-Tuesday
- By: HIRATSUKA, Masahiro (Tohoku University, Graduate School of Pharmaceutical Sciences, Sendai, Japan)
- Co-author(s): Eiji Hishinuma: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
Fumika Akai: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
Masamitsu Maekawa: Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan
Nariyasu Mano: Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan
Noriyasu Hirasawa: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
Masahiro Hiratsuka: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan;Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan;Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan - Abstract:
Backgrounds
Dihydropyrimidinase (DHP), encoded by DPYS gene, is the second enzyme in the catabolic pathway of uracil and fluoropyrimidine drugs such as 5-fluorouracil. DHP catalyzes the hydrolysis of dihydrouracil and fluorodihydrouracil. Deficiency or low activity of DHP could cause severe adverse reactions during fluoropyrimidine therapy. Several .. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023