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Synthesis, identification, and biological activity of metabolites of two novel selective S1P1 agonists
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-052-Monday
- By: XIAO, Qiong (Beijing, China)
- Co-author(s): Qiong Xiao: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Xiaojian Wang: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Huaqing Cui: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Hui Wen: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Meiyang Xi: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Xiang Zhang: Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China - Abstract:
Backgrounds
SYL927 and SYL930 are selective S1P1 agonists under preclinical development. However, during their pharmacokinetic studies we detected two metabolites in rat blood that were tentatively identified as monohydroxylated metabolites of SYL927 and SYL930 based on LC–MS/MS dataAims
Identify the monohydroxylated metabolitesMethods
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Last update 28 September 2023