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Impact of Lansoprazole Coadministration on Pemetrexed-induced Hematotoxicity: Stereoselective Inhibition of Human Organic Anion Transporter 3 by Lansoprazole Enantiomers
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-E-025-Monday
- By: OKUDA, Masahiro (Mie University Hospital, Department of Pharmacy, Tsu, Japan)
- Co-author(s): Masahiro Okuda: Department of Pharmacy, Mie University Hospital, Tsu, Japan
Kenji Ikemura: Department of Pharmacy, Mie University Hospital, Tsu, Japan
Yugo Hamada: Department of Clinical Pharmacy and Biopharmaceutics, Mie University Graduate School of Medicine, Tsu, Japan
Chinatsu Kaya: Faculty of Pharmaceutical Sciences, Suzuka University of Medical Sciences, Suzuka, Japan
Tomoyuki Enokiya: Department of Pharmacy, Mie University Hospital, Tsu, Japan
Yuichi Muraki: Department of Pharmacy, Mie University Hospital, Tsu, Japan
Hiroki Nakahara: Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu, Japan
Hajime Fujimoto: Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu, Japan
Tetsu Kobayashi: Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu, Japan
Takuya Iwamoto: Department of Pharmacy, Mie University Hospital, Tsu, Japan - Abstract:
Backgrounds
Pemetrexed (PEM) is eliminated by tubular secretion via organic anion transporter 3 (hOAT3), however, no information was available on drug interaction between PEM and proton pump inhibitors (PPIs).
Aims
Effect of PPIs on PEM transport by hOAT3 was evaluated in vitro, and the impact of PPIs on hematological toxicity was analyzed.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023