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DISCOVERY AND BIOLOGICAL EVALUATION OF NOVEL 1,2,4-TRIAZINE DERIVATIVES AS C-MET KINASE INHIBITORS
- In: Poster Session
- At: Düsseldorf (Germany) (2015)
- Type: Poster
- By: LABOUTA, Ibrahim (Alexandria University, Faculty of Pharmacy, Pharmaceutical Chemistry, Alexandria, Canada)
- Co-author(s): Ibrahim Labouta
- Abstract:
Tyrosine kinase c-Met is the high-affinity receptor for hepatocyte growth factor (HGF) and HGF/c-Met axis is often dysregulated in tumors. Recent strategies have been employed to interrupt the c-Met signaling pathway. Significant progress was made to develop small-molecule c-Met inhibitors, some of which reached clinical trials. Among heterocycles
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Last update 28 September 2023