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Simultaneous rapid separation and determination of fosphenytoin, phenytoin and their main metabolite 4'-hydroxyphenytoin in human plasma using isocratic reversed-phase HPLC
- In: SIG Individualised Medicine - Posters
- At: Beijing (China) (2007)
- Type: Poster
- Poster code: IM-P-004
- By: MA, Chunlai (Huashan Hospital, Fudan University, Shanghai, China)
- Co-author(s): Jiao, Zheng (Huashan Hospital, Fudan University, SHANGHAI, China)
Ying, Yinqing (Shanghai Health School, SHANGHAI, China)
Shi, Xiaojin (Huashan Hospital, Fudan University, SHANGHAI, China) - Abstract:
OBJECTIVE To develop a simple reversed-phase high-performance liquid chromatography (HPLC) method for the simultaneous determination of the antiepileptic drugs (AEDs) phenytoin (PHT), its prodrug fosphenytoin (FOS), and its metabolite 4′-hydroxyphenytoin (4′-HPPH) in human plasma. METHODS Plasma sample (100 μL) pre-treatment involved
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Last update 28 September 2023