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Effect of Hepatic and Renal Functions of Pharmacokinetics of Naproxen in Guinea Pigs: Acyl Glucuronide Concentration and Irreversible Binding to Plasma Protein
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-080-Monday
- By: IWAKI, Masahiro (Kindai University, Faculty of Pharmacy, Higashi-Osaka, Japan)
- Co-author(s): Masahiro Iwaki: Department of Pharmacy, Kindai University, Osaka, Japan
Taro Ogiso: Department of Pharmacy, Kindai University, Osaka, Japan
Hiroaki Shimada: Department of Pharmacy, Kindai University, Osaka, Japan
Atsushi Kawase: Department of Pharmacy, Kindai University, Osaka, Japan - Abstract:
Backgrounds
Glucuronide metabolite of NSAIDs including naproxen (NA) forms covalent binding with proteins and triggers anaphylaxis. Glucuronide of NSAIDs is mostly generated at liver and kidney, and excreted in bile, urine and blood.Aims
We aimed to determine effect of hepatic and renal dysfunctions on plasma concentrations of NA and its two major.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023