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In vitro investigation of Russian original benzodiazepine phenazepam pharacokinetics: cell culture with substrate-inhibitor panel in microbioreactor
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-E-015-Monday
- By: IVASHCHENKO, Dmitriy (Russian Medical Academy of Continuous Professional Education, Moscow, Russia, Moscow, Russian Federation)
- Co-author(s): Dmitriy Ivashchenko: Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
Andrey Poloznikov: SRC Bioclinicum, Moscow, Russian Federation
Sergey Nikulin: SRC Bioclinicum, Moscow, Russian Federation
Lyudmila Savchenko: Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
Eugeniy Bryun: Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
Dmitriy Sychev: Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation - Abstract:
Backgrounds
Phenazepam (brom-dihydrochlorphenyl-benzodiazepine) is a very common benzodiazepine drug in post-soviet countries. Although it was introduced in 1970s, there was no significant information about liver metabolism of phenazepam. It was hypothesized, that CYP3A-family enzymes could oxidize it, but the assumption required confirmation.Aims
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Last update 28 September 2023