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Nitrofurantoin permeability through Caco-2 cells: a parameter to develop new oral 5-nitro-heterocyclic compounds with potential activity against Multirresistant Staphylococcus aureus
- In: SIG Posters
- At: Amsterdam (the Netherlands) (2012)
- Type: Poster
- Poster code: DDD-P-01
- By: BALLERINI FERNANDES, Mariane (University of São Paulo, Pharmacy, São Paulo, Brazil)
- Co-author(s): Gonçalves, J.E. (University of São Paulo, São Paulo, Brazil)
Costa Tavares, L. (University of São Paulo, São Paulo, Brazil)
Storpirtis, S. (University of São Paulo, São Paulo, Brazil) - Abstract:
New 5-nitro-heterocyclic compounds have shown potential
..
in vitro
activity against multidrug-resistant
S. aureus
, being important and necessary the oral bioavailability evaluation as next stage in the development of a new drug. Nitrofurantoin, a 5-nitro-heterocyclic agent used in urinary infections, presents high oral bioavailability (?90%). This The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023