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A novel synthetic prodrug of flurbiprofen with good oral drug-like behaviors and improved safety profile
- In: Posters C - Drug Design and Discovery
- At: PSWC, Melbourne (Australia) (2014)
- Type: Poster
- Poster code: PC-015
- By: YANG, Ling (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China, Laboratory of Pharmaceutical Resource Discovery, Dalian, China)
- Co-author(s): Ning, Jing (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China)
Ge, Guang-Bo (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China)
Li, Yan (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China)
Li, Shi-Yang (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China) - Abstract:
Background: Flurbiprofen (FPF), a clinical used non-steroidal anti-inflammatory drug (NSAID), causes serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation.
Aims: To improve its oral drug-like behaviors and safety profile, a series of prodrugs for flurbiprofen were designed based on the tissue.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
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Last update 28 September 2023