Export this Abstract | Print this Abstract | Add to my preferred Abstracts list | My preferred Abstracts list (1) | Back to Search
Development of long-lasting stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells
- In: Poster Presentation
- At: Stockholm (Sweden) (2017)
- Type: Poster
- Poster code: P-A-033-Tuesday
- By: OTAKA, Akira (Insutitute of Biomedical Sciences, Tokushima University, Japan, Tokushima, Japan)
- Co-author(s): Akira Otaka: Insutitute of Biomedical Sciences, Tokushima University, Tokushima, Japan
Keisuke Aihara: Insutitute of Biomedical Sciences, Tokushima University, Tokushima, Japan
Tetsuro Yoshimaru: Institute for Genome Research, Tokushima University, Tokushima, Japan
Akira Shigenaga: Insutitute of Biomedical Sciences, Tokushima University, Tokushima, Japan
Toyomasa Katagiri: Institute for Genome Research, Tokushima University, Tokushima, Japan - Abstract:
Backgrounds
A novel estrogen signaling regulator: brefeldin A-inhibited guanine nucleotide-exchange protein 3 (BIG3), which is overexpressed in a majority of breast cancers. BIG3 captures prohibitin 2 (PHB2) in the cytoplasm of cancer cells and inhibits the suppression of ERα signaling pathways. Based on these findings, ERα activity-regulator.. The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress.
Please login
Last update 28 September 2023